The extracellular‐signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK‐expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation (...) of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. BioEssays 25:1085–1095, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long‐standing and deep‐routed “dogma” in neuroscience, established at the beginning of the 20th century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult mouse brain. The scepticism in accepting adult neurogenesis has now turned into a rush to find applications to alleviate or cure the devastating diseases that affect the CNS. Here we highlight a number (...) of methodological, technical and conceptual drawbacks responsible for the historical denial of adult neurogenesis. Furthermore, we discuss old and new issues that need to be faced before NSC or endogenous neurogenesis can safely enter into the doctor's bag for therapies. BioEssays 30:135–145, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Translation of Aristotle's Physics I-II into Portuguese, with commentaries. Tradução para o português dos livros I e II da Física de Aristóteles, com comentários.

This is an introductory handbook for some of the main themes around the notion of predication in Aristotle. It does not aim at being exhaustive, but only sketches some important lines about the subject; it contains an introductory essay, besides the translation (into Portuguese) and commentary of basic texts (such as Posterior Analytics I-22, Categories 1-5, Interpretation 1-6 etc.).

This book discusses Aristotle’s notions of essence and substance as they are developed in Metaphysics ZH. I examine Aristotle's argument at length and defends an unorthodox interpretation according to which his motivation is to provide an answer against a conflation between criteria for existential priority (delivering substances as primary beings) and criteria for explanatory priority (delivering essences as primary principles).

This book uses mathematical models of language to explain why there are certain gaps in language: things that we might expect to be able to say but can't. For instance, why can we say I ran for five minutes but not *I ran to the store for five minutes? Why is five pounds of books acceptable, but *five pounds of book not acceptable? What prevents us from saying *sixty degrees of water to express the temperature of the water in a (...) swimming pool when sixty inches of water can express its depth? And why can we not say *all the ants in my kitchen are numerous? The constraints on these constructions involve concepts that are generally studied separately: aspect, plural and mass reference, measurement, and distributivity. In this book, Lucas Champollion provides a unified perspective on these domains, connects them formally within the framework of algebraic semantics and mereology, and uses this connection to transfer insights across unrelated bodies of literature and formulate a single constraint that explains each of the judgments above. (shrink)

An old and well-known objection to non-classical logics is that they are too weak; in particular, they cannot prove a number of important mathematical results. A promising strategy to deal with this objection consists in proving so-called recapture results. Roughly, these results show that classical logic can be used in mathematics and other unproblematic contexts. However, the strategy faces some potential problems. First, typical recapture results are formulated in a purely logical language, and do not generalize nicely to languages containing (...) the kind of vocabulary that usually motivates non-classical theories—for example, a language containing a naïve truth predicate. Second, proofs of recapture results typically employ classical principles that are not valid in the targeted non-classical system; hence, non-classical theorists do not seem entitled to those results. In this paper, we analyze these problems and provide solutions on behalf of non-classical theorists. To address the first problem, we provide a novel kind of recapture result, which generalizes nicely to a truth-theoretic language. As for the second problem, we argue that it relies on an ambiguity and that, once the ambiguity is removed, there are no reasons to think that non-classical logicians are not entitled to their recapture results. (shrink)

The aim of this article is to show that, at least from a historical point of view and during the period addressed, different philosophical traditions within the University of Buenos Aires had their own political inscriptions. Thus, these study areas were established in the Faculty through important theoretical and political discussions. The article highlights moments of conflict and also determines four theoretical-political traditions to be considered: one neo-tomist and nationalist, one phenomenological and liberal, one metaphysical and corporative, and a fourth (...) scientific and filo-communist. (shrink)

I discuss in this paper the six requirements Aristotle advances at Posterior Analytics A-2, 71b20-33, for the premisses of a scientific demonstration. I argue that the six requirements give no support for an intepretation in terms of “axiomatization”. Quite on the contrary, the six requirements can be consistently understood in a very different picture, according to which the most basic feature of a scientific demonstration is to explain a given proposition by its appropriate cause.

I examine Aristotle’s definition of scientific knowledge in Posterior Analytics 71b 9-12 and try to understand how it relates to the sophistical way of knowing and to "kata sumbebekos knowledge". I claim that scientific knowledge of p requires knowing p by its appropriate cause, and that this appropriate cause is a universal (katholou) in the restricted sense Aristotle proposes in 73b 26-27 ff., i.e., an attribute coextensive with the subject (an extensional feature) and predicated of the subject in itself (an (...) intensional feature). Kata sumbebekos knowledge, on the other hand, can occur even when the predicate of a conclusion is coextensive with its subject and is proved by a convertible meson which is not the most appropriate from an explanatory standpoint. (shrink)

Translation of Aristotle's Posterior Analytics I into Portuguese, with a few notes, experimental glossary and introduction. The translation, which was made at 2003/4, was preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

Translation of Aristotle's Metaphysics IV and VI, with notes. The translation is preliminary and intended as a provisional teaching tool to be also used in seminars and discussions with peers in order to reach a more elaborated version.

This paper examines Aristotle’s notion of priority with the specific aim of capturing the sort of priority that characterizes the primacy of substances in his metaphysics. I reject the traditional interpretation, which understands the ontological priority of substances in terms of independent existence. But there are rather two sorts of priority: the ontological priority of substances should be understood in terms of completeness, whereas the ontological priority of “substances-of-something” (the essences) is a causal-explanatory priority. Furthermore, an important piece of Aristotle’s (...) argument against Platonism is that these two sorts of priority – namely, the completeness priority and the causal-explanatory priority – should be kept distinct. (shrink)

I discuss Aristotle's anomalous terminology in Physics A.1 (involving "universals" and "particulars") and its coherence with Aristotle's notion of scientific demonstration.

The paper generalizes Van McGee's well-known result that there are many maximal consistent sets of instances of Tarski's schema to a number of non-classical theories of truth. It is shown that if a non-classical theory rejects some classically valid principle in order to avoid the truth-theoretic paradoxes, then there will be many maximal non-trivial sets of instances of that principle that the non-classical theorist could in principle endorse. On the basis of this it is argued that the idea of classical (...) recapture, which plays such an important role for non-classical logicians, can only be pushed so far. (shrink)

Tradução preliminar em pré-print. A Tradução definitiva é a de 2009.

This paper discusses some issues concerning the definition of moral virtue in Nicomachean Ethics 1106b 36- 1107a 2. It is reasonable to expect from a definition the complete enumeration of the relevant features of its definiendum, but the definition of moral virtue seems to fail in doing this task. One might be tempted to infer that this definition is intended by Aristotle as a mere preliminary account that should be replaced by a more precise one. The context of the argument (...) Aristotle develops in Book II of his NE give us some help. I argue that the definition of moral virtue, once considered in the light of its context, is far from being an incomplete and provisional account: it rather introduces coherently the same notion of moral virtue that Aristotle employs in other texts (as in Nicomachean Ethics VI 13). My main proposal is that the way in which "hexis" is understood in the context of previous chapters allows Aristotle to encode in it the notion of an ability to do the right things regularly. Thus, moral virtue is a "hexis prohairetike etc.", but the ability to do the right things regularly is already encoded in the occurrence of "hexis" in the definiens account of moral virtue, as if Aristotle meant "hexis [praktike] prohairetike". (shrink)

This paper attempts to clarify the nature and the importance of a third kind of sophistic argument that is not always found in the classification of those arguments in the secondary literature. An argument of the third kind not only is a valid one, but is also constituted of true propositions. What makes it a sophistic argument is the fact that it produces a false semblance of scientific explanation: its explanation seems to be appropriate to the explanandum without being so. (...) Evidence from this kind of argument comes from Sophistic Refutations 11, and Brison’s attempt to square the circle should be counted as one of its instances. (shrink)

Translation of Aristotle's Posterior Analytics II into Portuguese, with a few notes, experimental glossary and introduction. The translation, which was made at 2002 (with a new printing in 2004), was preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

This paper discusses the contrast between scientific knowledge and opinion as it is presented by Aristotle in Posterior Analytics A.33. Aristotle's contrast is formulated in terms of understanding or not understanding some "necessary items". I claim that the contrast can only be understood in terms of explanatory relevance. The "necessary items" are middle terms (or explanatory factors) that are necessary for the fully appropriate explanation. This approach gives a coherent interpretation of each step in the chapter.

One of the most fruitful applications of substructural logics stems from their capacity to deal with self-referential paradoxes, especially truth-theoretic paradoxes. Both the structural rules of contraction and the rule of cut play a crucial role in typical paradoxical arguments. In this paper I address a number of difficulties affecting noncontractive approaches to paradox that have been discussed in the recent literature. The situation was roughly this: if you decide to go substructural, the nontransitive approach to truth offers a lot (...) of benefits that are not available in the noncontractive account. I sketch a noncontractive theory of truth that has these benefits. In particular, it has both a proof- and a model-theoretic presentation, it can be extended to a first-order language, and it retains every classically valid inference. (shrink)

Translation of Aristotle's Metaphysics I-III into Portuguese, with a few notes and introduction. The translation, which was made at 2007, is preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

I discuss the argument Aristotle ascribes to Parmenides at Physics 186a23-32. I discuss (i) the reasons why Aristotle considers it as eristic and inconclusive and (i) the solution (lusis) Aristotle proposes against it.

In Posterior Analytics 71b9 12, we find Aristotle’s definition of scientific knowledge. The definiens is taken to have only two informative parts: scientific knowledge must be knowledge of the cause and its object must be necessary. However, there is also a contrast between the definiendum and a sophistic way of knowing, which is marked by the expression “kata sumbebekos”. Not much attention has been paid to this contrast. In this paper, I discuss Aristotle’s definition paying due attention to this contrast (...) and to the way it interacts with the two conditions presented in the definiens. I claim that the “necessity” condition ammounts to explanatory appropriateness of the cause. (shrink)

I discuss three kinds of relationship between ends and means (or "things that promote ends") in the Aristotelian ethical theory, in order to clarify how moral virtues and phronesis are related both in adopting ends and in determining means for virtuous actions. Phronesis seems to be mainly charged with determining means for an end given by the moral virtues, but it must involve some conception of ends too. Phronesis cannot be parasitic on moral virtue concerning the conception of ends, for (...) otherwise it will lack intrinsic moral value. I argue that the intrinsic moral value of phronesis can be better understood through a certain kind of relation between means and ends that has not received much attention. (shrink)

I discuss in this paper Aristotle’s definition of nature in Physics 192b 20-23. I intend to prove that this definition has to be taken as a set of three (not only two) conditions: the first condition just establishes that nature is a sort of cause; the second condition concerns the relationship between nature and the natural thing that has it as a cause; the third condition concerns the relationship between nature and the properties that natural things have from nature’s causality.

This paper explores some aspects of Aristotle’s notion of subject for predications. I examine the argument Aristotle develops in Posterior Analytics I.22, 83a1-14. I argue that the notion advanced by Aristotle in that argument is different from the one found in his Categories, although they are far from being incompatible with each other. I also add some philological considerations to justify the Portuguese translation of “hypokeimenon” as “algo subjacente” (“underlying thing”) instead of “sujeito” (“subject”).

I argue that Aristotle’s teleology in natural science (more specifically, in biology) is not incompatible with his admissions of the “brute necessity” of the movements of matter. Aristotle thinks that the brute necessity emerging from the movements of matter is not sufficient to explain why living beings are what they are and behave the way they behave. Nevertheless, Aristotle takes this brute necessity to be a sine qua non condition in biological explanations. The full explanation of the features of living (...) beings requires the hylomorphic model, in which the brute necessity belonging to the matter is subordinated to the teleological causality of the form. The model for which I argue is pretty much Balme’s “cybernetic”. However, I explore some aspects of Aristotle’s texts that have not received much attention in the recent literature. (shrink)

Tradução dos livros Z e H da Metafísica de Aristóteles, com introdução e notas. Translation of Aristotle's Metaphysics Books VII and VIII into Portuguese, with Introduction and Notes.

My aim is to examine Aristotle's hylomorphism as a model for scientific explanation of living beings. I argue that the issue of matter-form relation should be connected with the opposition between the necessity of material and efficient causes and the teleology of forms. Form (as "telos") is a principle able to organize the appropriate conjunction of material and efficient causes. Formal and final causes are not a trick for filling the "gap in causation", nor are they bare heuristic tools for (...) inquiring into the "true" causes. The primacy of formal and final causes guarantees an appropriate account of material and efficient causes inasmuch as form and "telos" are responsible for bending and organizing the original dispositions of the material elements. (shrink)

I discuss some of Aristotle’s scattered remarks from which one can construct his conception of matter. Aristotle seems to oscillate between two conceptions: one in which matter is the principle of becoming, another in which matter is a constituent element with no contribution for processes of becoming. Sometimes Aristotle takes matter as a thing independent in itself, and the correlated form is a feature that does not contribute to the matter’s essence, nor is a necessary condition for its existence. But (...) sometimes Aristotle takes matter as a constituent element the existence of which depends on the whole thing it is the matter of. These different approaches to matter seem to suggest an inconsistent theory of matter. However, I argue that, quite to the contrary, Aristotle has a consistent theory about matter. One of my main points is to distinguish contexts in which Aristotle is indeed talking about matter in general from contexts in which he uses the term “matter” to refer to a given thing that was previously taken as matter and to talk about that thing not qua matter, but qua the thing it is. (shrink)

Translation of passages of Aristotle's De Anima into Portuguese. The passages are these: I.1, I.4 (the 'Rylean passage'); II.1-6; III.1-8. The translation is preliminary.

Bietti, Tilston and Bangerter take an evolutionary approach towards memory transmission and storytelling, arguing that storytelling plays a central role in the creation and transmission of cultural information. They suggest that storytelling is a vehicle to transmit survival‐related information that helps to avoid the costs involved in the first‐hand acquisition of that information and contributes to the maintenance of social bonds and group‐level cooperation. Furthermore, Bietti et al. argue that, going beyond storytelling’s individualist role of manipulating the audience to enhance (...) fitness of the narrator, that these adaptive functions of storytelling may well be assigned to other forms of language use besides narration (e.g., instructional discourse and argumentation). Based on this evidence, Bietti and colleagues claim that the specific adaptive function of storytelling lies in making sense of non‐routine, uncertain, or novel situations, thereby enabling collective sensemaking. (shrink)

This is a translation of Aristotle's Metaphysics V (Delta) 18-30 into Portuguese. (A different publication, with a different DOI, presents the commentaries that accompany this translation).

Public participation in scientific research has gained prominence in many scientific fields, but the theory of participatory research is still limited. In this paper, we suggest that the divergence of values and goals between academic researchers and public participants in research is key to analyzing the different forms this research takes. We examine two existing characterizations of participatory research: one in terms of public participants' role in the research, the other in terms of the virtues of the research. In our (...) view, each of these captures an important feature of participatory research but is, on its own, limited in what features it takes into account. We introduce an expanded conception of norms of collaboration that extends to both academic researchers and public participants. We suggest that satisfying these norms requires consideration of the two groups' possibly divergent values and goals, and that a broad characterization of participatory research that starts from participants' values and goals can motivate both public participants’ role in the research and the virtues of the research. The resulting framework clarifies the similarities and differences among participatory projects and can help guide the responsible design of such projects. (shrink)

I discuss an important feature of the notion of cause in Post. An. 1. 13, 78b13–28, which has been either neglected or misunderstood. Some have treated it as if Aristotle were introducing a false principle about explanation; others have understood the point in terms of coextensiveness of cause and effect. However, none offers a full exegesis of Aristotle's tangled argument or accounts for all of the text's peculiarities. My aim is to disentangle Aristotle's steps to show that he is arguing (...) in favour of a logical requirement for a middle term's being the appropriate cause of its explanandum. Coextensiveness between the middle term and the attribute it explains is advanced as a sine qua non condition of a middle term's being an appropriate or primary cause. This condition is not restricted either to negative causes or to middle terms in second‐figure syllogisms, but ranges over all primary causes qua primary. (shrink)

This article examines three passages of De caelo in order to discuss Aristotle’s epistemological attitude towards the theories advanced by him and towards the possibility of progress in the scientific research of the celestial world. I argue that, although the possibility of progress in scientific investigation is not central in Aristotle’s reflections, progress is not ruled out either as impossible or as undesirable.

Esta investigación forma parte de un Proyecto de Innovación Docente de la Universidad de Málaga (PIE19-179) que se inició en 2019 y que continuó en 2022 con el grupo de investigación PROCING de la Universidad de Huila-CORHUILA. El objetivo era tratar de desarrollar en el alumnado universitario el pensamiento crítico a través de la lectura crítica y la metodología Scrum como estrategias. La recopilación de datos se llevó a cabo con un cuestionario dividido en cuatro dimensiones y compuesto por 68 (...) ítems. Si bien los resultados del post-test en ambas universidades no son significativos, hubo un aumento en las respuestas a «siempre» en un 4% para los participantes de la Universidad de Málaga (España) y de un 6% en los estudiantes de la Universidad de Huila-CORHUILA (Colombia). (shrink)

This paper examines some difficulties in Aristotle’s argument in Metaphysics VII 3 and proposes a point of view in which there is no serious conflict between ousia taken as hypokeimenon and ousia taken as eidos.

It is not uncommon among theorists favoring a deviant logic on account of the semantic paradoxes to subscribe to an idea that has come to be known as ‘classical recapture’. The main thought underpinning it is that non-classical logicians are justified in endorsing many instances of the classically valid principles that they reject. Classical recapture promises to yield an appealing pair of views: one can attain naivety for semantic concepts while retaining classicality in ordinary domains such as mathematics. However, Julien (...) Murzi and Lorenzo Rossi have recently suggested that revisionary approaches to truth breed revenge paradoxes when they are coupled with the thought that classical reasoning can be recaptured in certain circumstances. What’s novel about the paradoxes they put forward is that they cannot be dismissed so easily. The concepts used to generate these paradoxes—those of paradoxicality and unparadoxicality—are concepts that non-classical theorists need in order to offer a diagnosis of the truth-theoretic paradoxes. My goal in this paper is to argue that non-classical theorists can represent the concept of paradoxicality without falling prey to revenge paradoxes. In particular, I will show how to provide a formal fixed-point semantics for a language extended with a paradoxicality predicate that adequately expresses the non-classical logician’s notion of paradoxicality. (shrink)

In their paper “Brain Data in Context: Are New Rights the Way to Mental and Brain Privacy?” Susser and Cabrera (2024) argue against the notion that specific rights may be necessary to protect “brai...

I discuss Aristotle's treatment of essence and definition in Metaphysics VII.4. I argue that it is coherent and perfectly in accord with its broader context. His discussion in VII.4 offers, on the one hand, minimal criteria for what counts as definition and essence for whatever kind of object, but also, on the other hand, stronger criteria for a primary sort of definition and essence—and thereby it serves the interest of book VII in pointing to the explanatory power of the essence (...) of composite substances. (shrink)

The idea of classical recapture has played a prominent role for non-classical logicians. In the specific case of non-classical theories of truth, although we know that it is not possible to retain classical logic for every statement involving the truth predicate, it is clear that for many such statements this is in principle feasible, and even desirable. What is not entirely obvious or well-known is how far this idea can be pushed. Can the non-classical theorist retain classical logic for every (...) non-paradoxical statement? If not, is she forced to settle for a very weak form of Classical Recapture, or are there robust versions of classical recapture available to her? These are the main questions that I will address in this paper. As a test case I will consider a paracomplete account of the truth-theoretic paradoxes and I will argue for two claims. First, that it is not possible to retain the law of excluded middle for every non-paradoxical statement. Secondly, that there are no robust versions of classical recapture available to the paracomplete logician. (shrink)

Translation of Aristotle's Parts of Animals Book I into Portuguese, with full commentaries.

Tradução para o Português de Ethica Nicomachea VI.

Aristotle contrasts episteme and doxa through the key notions of universal and necessary. These notions have played a central role in Aristotle’s characterization of scientific knowledge in the previous chapters of APo. They are not spelled out in APo I.33, but work as a sort of reminder that packs an adequate characterization of scientific knowledge and thereby gives a highly specified context for Aristotle’s contrast between episteme and doxa. I will try to show that this context introduces a contrast in (...) terms of explanatory claims: on the one hand, episteme covers those claims which capture explanatory connections that are universal and necessary and thereby deliver scientific understanding; on the other hand, doxa covers the explanatory attempts that fail at doing so. (shrink)

Norm theory (Kahneman & Miller, 1986) described a tendency for people to associate stronger regret with a negative outcome when it is a result of an exception (abnormal behavior) compared to when it is a result of routine (normal behavior). In two pre-registered studies, we conducted a replication and extension of three classic experiments on past behavior exception/routine contrasts (N = 684). We successfully replicated Kahneman and Miller’s (1986) experiments with the classic hitchhiker-scenario (Part 1) and car accident-scenario (Part 2). (...) In both cases, participants examined negative outcomes and tended to indicate a protagonist who deviated from own past behavior as more regretful than another who followed routine. Pre-registered extensions also showed effects for ratings of social norms, negative affect, and perceived luck. We did not find support for the Miller and McFarland (1986) experiment robbery scenario (Part 3) using a compensation measure, in that compensation to a victim of a robbery was not significantly different comparing exceptional and routine circumstances. However, a pre-registered extension showed that robbery under exceptional circumstances was regretted more than robbery under routine circumstances. We discuss implications for current and future research. (shrink)